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ROS detoxification is mediated by both enzymatic and non-enzymatic components

ZIP14 is a divalent iron import protein that is distributed in both the proximal and distal tubules, and mainly takes up nontransferrin-bound iron from the lumen[141, 142]

Large clinical trials running for several years show that GLP-1s not only improve sugar and weight but also reduce heart and kidney risks in many people with type 2 diabetes, with an acceptable safety profile when monitored

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This effect can be explained based on its antioxidant and telomerase-inducing activity, which slows down the aging of the skin and improve overall appearance [9]