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Abbreviations Akt: Protein kinase B BMI: Body mass index cAMP: Cyclic adenosine monophosphate CGRP: Calcitonin gene-related peptide DM: Diabetes mellitus DPP: 4-dipeptidyl peptidase-4 GLP: 1-glucagon-like peptide-1 GLP: 1R-glucagon-like peptide-1 receptor HbA1c: Glycated hemoglobin IGF: Insulin-like growth factor MAPK: Mitogen-activated protein kinase mTOR: Mammalian target of rapamycin NF: B-nuclear factor B PI3K: Phosphoinositide 3-kinase PKA: cAMP-dependent protein kinase SGLT: 2-sodium-glucosecotransporter-2 T2DM: Type 2 diabetes mellitus References Iijima, T., Shibuya, M., Ito, Y., & Terauchi, Y

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Yagiz et al., 2021)

P9 protein specifically binds to intercellular adhesion molecule-2 (ICAM-2), activating macrophage IL-6 signaling and significantly increasing uncoupling protein-1 (UCP-1) expression in interscapular brown adipose tissue (BAT) [94, 95]

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